Synergistic Ingredients — Noni, Lysine & Hyaluronic Acid
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TRAINING MODULE: Synergistic Ingredients — Noni, Lysine & Hyaluronic Acid
Formula 1 Equine Education Portal
Module Overview
This module teaches representatives how Noni, Lysine, and Hyaluronic Acid (HA) work together to support joint health, soft tissue repair, immune balance, and overall recovery.
Reps must understand how these combinations influence real-world outcomes in injured, performance, or immune-compromised horses.
SECTION 1 — Synergy Breakdown by Pair
1. Noni + Hyaluronic Acid (HA)
Primary Focus: Joint lubrication • Anti-inflammatory support • Hydration • Immune modulation
Biological Interactions
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Hyaluronic Acid (HA):
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Provides lubrication and viscoelasticity to synovial fluid
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Supports cartilage homeostasis and slows degradation
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Enhances moisture retention in connective tissues
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Noni (iridoid-rich puree):
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Modulates inflammatory cytokines (TNF-α, IL-6, IL-1β)
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Acts as a natural COX-2 inhibitor → reduces pain and swelling
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Boosts antioxidant capacity through increased SOD and glutathione
Why This Combo Works
Together, Noni reduces inflammatory stress while HA restores lubrication.
This pair is excellent for:
✓ Joint rehab
✓ Performance horses
✓ Horses in active inflammation
✓ Age-related joint stiffness
Bonus Synergy:
Noni reduces oxidative damage, allowing HA to remain stable longer within joint tissues.
2. Noni + Lysine
Primary Focus: Collagen formation • Immune boosting • Tissue repair • Anti-viral protection
Biological Interactions
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Lysine:
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Drives collagen cross-linking (Types I & III)
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Supports tendon, ligament, and vascular repair
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Competes with arginine to slow viral replication
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Noni:
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Increases macrophage and fibroblast activity → faster wound healing
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Supports immune activation and cellular turnover
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Inhibits viral penetration into cells
Why This Combo Works
Together, these two:
✓ Accelerate connective tissue healing
✓ Reduce viral stress loads
✓ Stabilize inflammation without suppressing the immune system
Ideal for:
• Soft tissue injuries
• Post-surgical healing
• Horses with compromised immunity
• Chronic inflammation cases
3. Lysine + Hyaluronic Acid (HA)
Primary Focus: Joint structure • Hydration • Anti-catabolism • Collagen support
Biological Interactions
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Lysine:
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Provides the building blocks for new collagen
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Supports cartilage and soft tissue regeneration
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Enhances calcium absorption for bone margin repair
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Hyaluronic Acid:
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Retains water within the extracellular matrix (ECM)
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Protects tissues during movement and recovery
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Reduces cartilage breakdown under mechanical stress
Why This Combo Works
Together, they:
✓ Hydrate tissues
✓ Support regrowth and remodeling
✓ Reduce breakdown under load
✓ Strengthen collagen-rich structures (tendons, skin, cartilage)
Excellent for:
• Joint degeneration
• High-impact athletes
• Chronic cartilage wear
• Older horses needing structural support
SECTION 2 — The Triple Synergy
Noni + Lysine + Hyaluronic Acid (HA)
The Complete Repair Triangle
Combined Focus:
Structural Repair (Lysine)
Inflammation Control (Noni)
Hydration & Lubrication (HA)
Why This Trio Is Exceptional
This combination targets every stage of the healing process:
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Stops Breakdown:
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Calms cytokine storms
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Reduces oxidative and inflammatory damage
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Restores Stability:
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Improves lubrication in joints
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Rehydrates connective tissues
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Builds Back Stronger:
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Accelerates collagen synthesis
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Fuels tendon, ligament, and cartilage repair
Best Uses for All Three Together:
✓ Horses with joint degeneration
✓ Tendon/ligament tears
✓ Post-race or post-injury rehab
✓ Immune dysregulation
✓ Ulcers or chronic inflammation cases
✓ Senior horses with stiffness + soft tissue decline
This trio is one of the most powerful “whole-body repair” strategies in equine nutrition.
End of Module Summary
Reps should now understand:
✓ How each ingredient works independently
✓ What each pair accomplishes biologically
✓ Why combining all three dramatically enhances recovery and performance
✓ When to recommend these combinations for real-world cases
